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Dr C Leroux

Dr Caroline Leroux, DR2 INRA,

Responsable de l'équipe PR2T

CLX_NEW

Formée à l'Université de Caen puis à Lyon 1, j'ai obtenu mon doctorat en virologie pour mon travail sur les lentivirus des petits ruminants. J'ai ensuite rejoint le laboratoire du Pr Ronald C Montelaro à l'université de Pittsburgh (PA, USA) en tant qu'associé de recherche senior pendant plus de 3 ans. J'ai travaillé sur l'évolution moléculaire d'EIAV (Equine Infectious Anemia Virus) chez les équidés au cours de la progression de la maladie et sur la compartimentalisation des quasi-espèces d'HIV chez les patients infectés.

Je suis rentrée à Lyon pour démarrer mon groupe de recherche "rétrovirus, Evolution et Cancer." J'ai obtenu mon HDR en 2001 et rejoint l'INRA (Institut National de la Recherche Agronomique) en 2002.

J'ai développé mon expertise sur les rétrovirus animaux et les mécanismes associés au développement et à la progression des maladies. Dans ce contexte, je travaille sur plusieurs rétrovirus chez les animaux de rente tels que SRLV (Small Ruminant LentiVirus), JSRV (Jaagsiekte sheep retrovirus) et ENTV (Enzootic Nasal Tumor Virus) chez les ovins et caprins et EIAV (Equine Infectious Anemia Virus) chez les équidés.

J'ai concentré la majeure partie de mon travail sur les maladies pulmonaires. Mon principal intérêt est de comprendre les interactions entre les rétrovirus et les cellules hôtes au cours de l'établissement et  la progression de la maladie. Au cours des dernières années, j'ai développé plusieurs projets de recherche sur le cancer induit par les rétrovirus chez les ovins et les caprins mais également sur les cancers rares non viraux induits chez l'homme. J'ai eu la chance de développer mon groupe au plus près de la clinique, grâce à mes collègues travaillant en médecine humaine et vétérinaire. J'apprécie particulièrement de mener des projets aux frontières de la recherche fondamentale et de la médecine humaine ou vétérinaire.

https://www.researchgate.net/home

Voir aussi

Publications

  1. Belalmi N, Sid N, Bennoume O, Ouhida S, De Las Heras M, Leroux C. Evidence of jaagsiekte sheep retrovirus-induced pulmonary adenocarcinoma in Ouled Djellal breed sheep in Algeria, Vet Res Forum, 2020
  2. Leroux C, Cadore JL. Equine Infectious Anemia, Anipedia, 2020
  3. Furnon W, Fender P, Confort M-P, Desloire S, Nangola S, Kitidee K, Leroux C, Ratinier M, Arnaud F, Lecollinet S, Boulanger P, Hong SS. Remodeling of the actin network associated with the Non-Structural Protein (NS1) of West Nile Virus and formation of NS1-containing Tunneling Nanotubes.Viruses. 2019, 11, 901
  4. Maury JM, Merveilleux du Vignaux C, Drevet G, Zarza V, Chalabreysse L, Maisse C, Gineys B, Dolmazon C, Tronc F, Girard N, Leroux C. 2019. Activation of the mTOR/ Akt pathway in thymic epithelial cells derived from thymomas. PLoS One 14:e0197655.
  5. Chebib N, Archer F, Bobet-Erny A, Leroux C, Cottin V. 2018. Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration. Sci Rep 8:14698.
  6. Sid, N., N. El Houda Belalmi, L. Benhamza, S. Ouhida, M. Zebiri, A. Aydoğan, and C. Leroux. 2018. First case report of enzootic nasal adenocarcinoma in "Ouled Djellal"ewe in Algeria. Open Veterinary Journal 8:9-12. http://www.openveterinaryjournal.com/OVJ-2017-07-134%20Sid%20et%20al.pdf
  7. Maury, J. M., N. Girard, M. Tabutin, R. Grima, L. Chalabreysse, I. Pavlakovic, A. Sayag-Beaujard, C. Leroux, P. J. Souquet, O. Glehen, and F. Tronc. 2017. Intra-Thoracic Chemo-Hyperthermia for pleural recurrence of thymoma. Lung Cancer 108:1-6. https://www.ncbi.nlm.nih.gov/pubmed/28625619
  8. Gomes, M., F. Archer, N. Girard, B. Gineys, C. Dolmazon, A. Bobet Erny, J. F. Mornex, and C. Leroux. 2017. Blocked expression of key genes of the angiogenic pathway in JSRV-induced pulmonary adenocarcinomas. Vet Res 48:76.
  9. Cadore, J. L., A. Tortereau, S. Belluco, E. Segard, and C. Leroux. 2017. Guttural pouch mycosis in horses: An intriguing and mysterious disease. Equine Vet Educ in press.
  10. Leroux, C., and R. F. Cook. 2016. Equine infectious anaemia virus, p. 177-189. In D. Liu (ed.), Molecular Detection of Animal Viral Pathogens. CRC Press.
  11. Chebib, N., C. Khouatra, R. Lazor, F. Archer, C. Leroux, D. Gamondes, F. Thivolet-Bejui, J. F. Cordier, and V. Cottin. 2016. [Pulmonary lymphangioleiomyomatosis: From pathogenesis to management]. Rev Mal Respir 33:718-734.
  12. Bonnefont-Rebeix, C., C. Fournel-Fleury, F. Ponce, S. Belluco, D. Watrelot, S. E. Bouteille, S. Rapiteau, D. Razanajaona-Doll, J. J. Pin, C. Leroux, and T. Marchal. 2016. Characterization of a novel canine T-cell line established from a spontaneously occurring aggressive T-cell lymphoma with large granular cell morphology. Immunobiology 221:12-22.
  13. Bolfa, P., F. Barbuceanu, S. E. Leau, and C. Leroux. 2016. Equine infectious anaemia in Europe: Time to re-examine the efficacy of monitoring and control protocols? Equine Vet J 48:140-142.
  14. Monot, M., A. Erny, B. Gineys, S. Desloire, C. Dolmazon, A. Aublin-Gex, V. Lotteau, F. Archer, and C. Leroux. 2015. Early Steps of Jaagsiekte Sheep Retrovirus-Mediated Cell Transformation Involve the Interaction between Env and the RALBP1 Cellular Protein. J Virol 89:8462-8473.
  15. Monot, M., F. Archer, M. Gomes, J. F. Mornex, and C. Leroux. 2015. Advances in the study of transmissible respiratory tumours in small ruminants. Vet Microbiol 181:170-177.
  16. Cook, R. F., C. Leroux, and C. J. Issel. 2013. Equine infectious anemia and equine infectious anemia virus in 2013: a review. Vet Microbiol 167:181-204.
  17. Bolfa, P., M. Nolf, J. L. Cadore, C. Catoi, F. Archer, C. Dolmazon, J. F. Mornex, and C. Leroux. 2013. Interstitial lung disease associated with Equine Infectious Anemia Virus infection in horses. Vet Res 44:113.
  18. Archer, F., A. Abi-Rizk, S. Desloire, C. Dolmazon, B. Gineys, F. Guiguen, V. Cottin, J. F. Mornex, and C. Leroux. 2013. Lung progenitors from lambs can differentiate into specialized alveolar or bronchiolar epithelial cells. BMC Vet Res 9:224.
  19. Viginier, B., C. Dolmazon, I. Lantier, F. Lantier, F. Archer, C. Leroux, and C. Terzian. 2012. Copy Number Variation and Differential Expression of a Protective Endogenous Retrovirus in Sheep. PLos ONE 7:e41965.
  20. Lutringer-Magnin, D., N. Girard, J. Cadranel, C. Leroux, E. Quoix, V. Cottin, C. D. Signore, M. P. Lebitasy, G. Cordier, P. Vanhems, and J. F. Mornex. 2012. Professional Exposure to Goats Increases the Risk of Pneumonic-Type Lung Adenocarcinoma: Results of the IFCT-0504-Epidemio Study. PLos ONE 7:e37889.
  21. Bolfa, P. F., C. Leroux, A. Pintea, S. Andrei, C. Catoi, M. Taulescu, F. Tabaran, and M. Spinu. 2012. Oxidant-antioxidant imbalance in horses infected with equine infectious anaemia virus. Vet J 192:449-454.
  22. Archer, F., J. F. Mornex, and C. Leroux. 2012. Interplay between JSRV, an oncogenic retrovirus, and the pulmonary epithelium. Current Immunology Reviews 7:209-215.
  23. Cottin, V., F. Archer, C. Leroux, J. F. Mornex, and J. F. Cordier. 2011. Milestones in lymphangioleiomyomatosis research. Eur Respir Rev 20:3-6.
  24. Leroux, C., J. C. Cruz, and J. F. Mornex. 2010. SRLVs: a genetic continuum of lentiviral species in sheep and goats with cumulative evidence of cross species transmission. Curr HIV Res 8:94-100.
  25. Leroux, C., and J. F. Mornex. 2008. Retroviral infections in sheep and the associated diseases. Small Rumin Res 76:68-76.
  26. Kaufmann, C., M. Brechbuhl, A. Oevermann, S. Muller, K. Zimmer, M. Schonmann, C. Leroux, D. Weibel, and G. Bertoni. 2008. [Enzootic nasal adenocarcinoma in a dairy sheep flock]. Schweiz Arch Tierheilkd 150:297-302.
  27. Erhouma, E., F. Guiguen, Y. Chebloune, D. Gauthier, L. M. Lakhal, T. Greenland, J. F. Mornex, C. Leroux, and T. Alogninouwa. 2008. Small ruminant lentivirus proviral sequences from wild ibexes in contact with domestic goats. J Gen Virol 89:1478-1484.
  28. Varela, M., M. Golder, F. Archer, M. de Las Heras, C. Leroux, and M. Palmarini. 2007. A large animal model to evaluate the effects of Hsp90 inhibitors for the treatment of lung adenocarcinoma. Virology 371:206-215.
  29. Leroux, C., N. Girard, V. Cottin, T. Greenland, J. F. Mornex, and F. Archer. 2007. Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep. Vet Res 38:211-228.
  30. Bonnefont-Rebeix, C., T. Marchal, J. Bernaud, J. J. Pin, C. Leroux, S. Lebecque, L. Chabanne, and D. Rigal. 2007. Toll-like receptor 3 (TLR3): A new marker of canine monocytes-derived dendritic cells (cMo-DC). Vet Immunol Immunopathol 118:134-139.
  31. Boissin-Quillon, A., D. Piau, and C. Leroux. 2007. In silico segmentations of lentivirus envelope sequences. BMC Bioinformatics 8:99.
  32. Archer, F., E. Jacquier, M. Lyon, J. Chastang, V. Cottin, J. F. Mornex, and C. Leroux. 2007. Alveolar type II cells isolated from pulmonary adenocarcinoma: a model for JSRV expression in vitro. Am J Respir Cell Mol Biol 36:534-540.
  33. Suau, F., N. Girard, F. Archer, V. Cottin, S. Croze, J. F. Mornex, and C. Leroux. 2006. JSRV (jaagsiekte sheep retrovirus) et cancer du poumon associé chez le mouton. Virologie 10:287-299.
  34. Suau, F., V. Cottin, F. Archer, S. Croze, J. Chastang, G. Cordier, F. Thivolet-Bejui, J. F. Mornex, and C. Leroux. 2006. Telomerase activation in a model of lung adenocarcinoma. Eur Respir J 27:1175-1182.
  35. Craigo, J. K., T. J. Sturgeon, S. J. Cook, C. J. Issel, C. Leroux, and R. C. Montelaro. 2006. Apparent elimination of EIAV ancestral species in a long-term inapparent carrier. Virology 344:340-353.
  36. Leroux, C., R. C. Montelaro, E. Sublime, and J. L. Cadore. 2005. EIAV (equine infectious anemia virus): mieux comprendre la pathogénèse des infections lentivirales. Virologie 9:289-300.
  37. Salaun, B., B. de Saint-Vis, N. Pacheco, Y. Pacheco, A. Riesler, S. Isaac, C. Leroux, V. Clair-Moninot, J. J. Pin, J. Griffith, I. Treilleux, S. Goddard, J. Davoust, M. Kleijmeer, and S. Lebecque. 2004. CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol 164:861-871.
  38. Leroux, C., J. L. Cadore, and R. C. Montelaro. 2004. Equine Infectious Anemia Virus (EIAV): what has HIV's country cousin got to tell us? Vet Res 35:485-512.
  39. Chalabreysse, L., C. Leroux, J. F. Obadia, T. Greenland, F. Thivolet-Bejui, and J. F. Mornex. 2004. Apoptosis in right-ventricle biopsy is not predictive of graft survival. Transpl Int 17:362-365.
  40. Mornex, J. F., F. Thivolet, M. De las Heras, and C. Leroux. 2003. Pathology of human bronchioloalveolar carcinoma and its relationship to the ovine disease. Curr Top Microbiol Immunol 275:225-248.
  41. DeMartini, J. C., J. O. Carlson, C. Leroux, T. Spencer, and M. Palmarini. 2003. Endogenous retroviruses related to jaagsiekte sheep retrovirus. Curr Top Microbiol Immunol 275:117-137.
  42. Cook, R. F., S. J. Cook, S. L. Berger, C. Leroux, N. N. Ghabrial, M. Gantz, P. S. Bolin, M. R. Mousel, R. C. Montelaro, and C. J. Issel. 2003. Enhancement of equine infectious anemia virus virulence by identification and removal of suboptimal nucleotides. Virology 313:588-603.
  43. Carlson, J., M. Lyon, J. Bishop, A. Vaiman, E. Cribiu, J. F. Mornex, S. Brown, D. Knudson, J. DeMartini, and C. Leroux. 2003. Chromosomal distribution of endogenous Jaagsiekte sheep retrovirus proviral sequences in the sheep genome. J Virol 77:9662-9668.
  44. Howe, L., C. Leroux, C. J. Issel, and R. C. Montelaro. 2002. Equine infectious anemia virus envelope evolution in vivo during persistent infection progressively increases resistance to in vitro serum antibody neutralization as a dominant phenotype. J Virol 76:10588-10597.
  45. Craigo, J. K., C. Leroux, L. Howe, J. D. Steckbeck, S. J. Cook, C. J. Issel, and R. C. Montelaro. 2002. Transient immune suppression of inapparent carriers infected with a principal neutralizing domain-deficient equine infectious anaemia virus induces neutralizing antibodies and lowers steady-state virus replication. J Gen Virol 83:1353-1359.
  46. Leroux, C., J. K. Craigo, C. J. Issel, and R. C. Montelaro. 2001. Equine infectious anemia virus genomic evolution in progressor and nonprogressor ponies. J Virol 75:4570-4583.
  47. Tabib, A., C. Leroux, J. F. Mornex, and R. Loire. 2000. Accelerated coronary atherosclerosis and arteriosclerosis in young human-immunodeficiency-virus-positive patients. Coron Artery Dis 11:41-46.
  48. Li, F., C. Leroux, J. K. Craigo, S. J. Cook, C. J. Issel, and R. C. Montelaro. 2000. The S2 gene of equine infectious anemia virus is a highly conserved determinant of viral replication and virulence properties in experimentally infected ponies. J Virol 74:573-579.
  49. Gupta, P., C. Leroux, B. K. Patterson, L. Kingsley, C. Rinaldo, M. Ding, Y. Chen, K. Kulka, W. Buchanan, B. McKeon, and R. Montelaro. 2000. Human immunodeficiency virus type 1 shedding pattern in semen correlates with the compartmentalization of viral Quasi species between blood and semen. J Infect Dis 182:79-87.
  50. Lichtenstein, D. L., J. K. Craigo, C. Leroux, K. E. Rushlow, R. F. Cook, S. J. Cook, C. J. Issel, and R. C. Montelaro. 1999. Effects of long terminal repeat sequence variation on equine infectious anemia virus replication in vitro and in vivo. Virology 263:408-417.
  51. Cook, R. F., C. Leroux, S. J. Cook, S. L. Berger, D. L. Lichtenstein, N. N. Ghabrial, R. C. Montelaro, and C. J. Issel. 1998. Development and characterization of an in vivo pathogenic molecular clone of equine infectious anemia virus. J Virol 72:1383-1393.
  52. Lyon, M., C. Leroux, T. Greenland, J. Chastang, J. Patet, and J. F. Mornex. 1997. Presence of a unique parainfluenza virus 3 strain identified by RT-PCR in visna-maedi virus infected sheep. Vet Microbiol 57:95-104.
  53. Leroux, C., C. Lerondelle, J. Chastang, and J. F. Mornex. 1997. RT-PCR detection of lentiviruses in milk or mammary secretions of sheep or goats from infected flocks. Vet Res 28:115-121.
  54. Leroux, C., C. J. Issel, and R. C. Montelaro. 1997. Novel and dynamic evolution of equine infectious anemia virus genomic quasispecies associated with sequential disease cycles in an experimentally infected pony. J Virol 71:9627-9639.
  55. Leroux, C., J. Chastang, T. Greenland, and J. F. Mornex. 1997. Genomic heterogeneity of small ruminant lentiviruses: existence of heterogeneous populations in sheep and of the same lentiviral genotypes in sheep and goats. Arch Virol 142:1125-1137.
  56. Leroux, C., T. Greenland, and J. F. Mornex. 1996. Molecular characterization of field isolates of lentiviruses of small ruminants. AIDS Res Hum Retroviruses 12:427-429.
  57. Leroux, C., S. Vuillermoz, J. F. Mornex, and T. Greenland. 1995. Genomic heterogeneity in the pol region of ovine lentiviruses obtained from bronchoalveolar cells of infected sheep from France. J Gen Virol 76 ( Pt 6):1533-1537.
  58. Leroux, C., G. Cordier, I. Mercier, J. Chastang, M. Lyon, G. Querat, T. Greenland, R. Vigne, and J. F. Mornex. 1995. Ovine aortic smooth muscle cells allow the replication of visna-maedi virus in vitro. Arch Virol 140:1-11.
  59. Mornex, J. F., C. Leroux, T. Greenland, and D. Ecochard. 1994. From granuloma to fibrosis in interstitial lung diseases: molecular and cellular interactions. Eur Respir J 7:779-785.

Date de modification : 26 avril 2023 | Date de création : 10 janvier 2018 | Rédaction : C Leroux